A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 2,3-disubstituted-4-phenylquinolines

Authors
Tollefson, MB Vernier, WF Huang, HC Chen, FP Reinhard, EJ Beaudry, J Keller, BT Reitz, DB
Citation
Mb. Tollefson et al., A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 2,3-disubstituted-4-phenylquinolines, BIOORG MED, 10(3), 2000, pp. 277-279
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
277 - 279
Database
ISI
SICI code
0960-894X(20000207)10:3<277:ANCOAS>2.0.ZU;2-2
Abstract
A series of 2,3-disubstituted-4-phenylquinolines were prepared and were fou nd to inhibit the apical sodium co-dependent bile acid transporter (ASBT). Alkyl and ester substitution at the 3-position showed comparable activities while substitution at the 2-position was much more sensitive to the nature of the substituent. The synthesis and in vitro potency data are presented for this novel class of compounds. (C) 2000 Elsevier Science Ltd. All right s reserved.