Probing the extended binding determinants of oligosaccharyl transferase with synthetic inhibitors of asparagine-linked glycosylation

Authors
Ufret, MD Imperiali, B
Citation
Md. Ufret et B. Imperiali, Probing the extended binding determinants of oligosaccharyl transferase with synthetic inhibitors of asparagine-linked glycosylation, BIOORG MED, 10(3), 2000, pp. 281-284
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
281 - 284
Database
ISI
SICI code
0960-894X(20000207)10:3<281:PTEBDO>2.0.ZU;2-I
Abstract
Protein glycosylation is associated with many critical biological processes . In connection with studies on the mechanism of asparagine-linked glycosyl ation by the enzyme oligosaccharyl transferase, we have prepared peptide in hibitors that interact with the enzyme at nanomolar concentrations. Herein we describe efforts directed toward improving the binding properties of the se inhibitors. (C) 2000 Elsevier Science Ltd. All rights reserved.