Synthesis and study of a new adenine-acridine tandem, inhibitor of exonuclease III

Authors
Belmont, P Demeunynck, M Constant, JF Lhomme, J
Citation
P. Belmont et al., Synthesis and study of a new adenine-acridine tandem, inhibitor of exonuclease III, BIOORG MED, 10(3), 2000, pp. 293-295
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
293 - 295
Database
ISI
SICI code
0960-894X(20000207)10:3<293:SASOAN>2.0.ZU;2-K
Abstract
A new heterodimer adenine-chain-acridine containing a mixed amido-guanidini um linker chain was synthesized. To achieve the synthesis a new method of i ntroduction of aminoalkyl chain at position 9 of adenine was designed. The heterodimer interacts specifically with the abasic sites in DNA and inhibit s the major base excision repair enzyme in Escherichia coli, Exonuclease II I. (C) 2000 Elsevier Science Ltd. All rights reserved.