Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation

Late onset haemorrhagic cystitis (HC) occurs in 20-30% of allogeneic bone m arrow transplant patients. Human polyomavirus BK (BKV) (or less frequently adenovirus) may be involved in the pathogenesis of viral HC and can represe nt a serious post-transplant complication. Diagnosis and treatment of viral HC can be difficult and has an uncertain outcome. We report the efficacy o f sequential vidarabine in the treatment of a patient with severe BKV-assoc iated HC, despite the delay in implementing therapy.