Polypoid malignant melanoma is a peculiar morphological variant of melanoma
with a distinct exophytic pattern of growth. This form of melanoma is usua
lly very thick and the prognosis is accordingly poor. We present here a pre
viously undescribed form of Spitz naevus which had a similar polypoid exoph
ytic silhouette and marked cytological atypia. Despite these close morpholo
gical similarities, polypoid Spitz naevus evolves in a completely benign ma
nner, Morphologically, polypoid Spitz naevus can be distinguished from poly
poid melanoma by the absence of mitoses and by the prominent stromal reacti
on throughout the lesion.