E. Arranz et al., Identification by comparative genomic hybridization of genetic changes involved in tumoral progression of a T-cell non-Hodgkin lymphoma, CANC GENET, 117(1), 2000, pp. 41-44
Comparative genomic hybridization (CGH) was used to detect chromosomal imba
lances in tumor DNA from two relapsed samples obtained in stages II and III
of a T-cell non-Hodgkin lymphoma in order to identify genetic mechanisms i
nvolved in tumor progression of this neoplasm. With conventional cytogeneti
c techniques (CCT), a complex hyperdiploid karyotype was obtained in stage
IV. Using CGH analysis, a normal profile was observed in stage II, whereas
gains of 6p11.2, 7q11.2, 7q21-->q32, 7q34, 10p13, Xp11.4, and loss of 4q33-
->qter chromosomal regions were detected in stage IV. (C) Elsevier Science
Inc., 2000. All rights reserved.