Identification by comparative genomic hybridization of genetic changes involved in tumoral progression of a T-cell non-Hodgkin lymphoma

Authors
Arranz, E Martinez-Delgado, B Richart, A Osorio, A Cebrian, A Robledo, M Rivas, C Benitez, J
Citation
E. Arranz et al., Identification by comparative genomic hybridization of genetic changes involved in tumoral progression of a T-cell non-Hodgkin lymphoma, CANC GENET, 117(1), 2000, pp. 41-44
Citations number
12
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER GENETICS AND CYTOGENETICS
ISSN journal
01654608 → ACNP
Volume
117
Issue
1
Year of publication
2000
Pages
41 - 44
Database
ISI
SICI code
0165-4608(200002)117:1<41:IBCGHO>2.0.ZU;2-L
Abstract
Comparative genomic hybridization (CGH) was used to detect chromosomal imba lances in tumor DNA from two relapsed samples obtained in stages II and III of a T-cell non-Hodgkin lymphoma in order to identify genetic mechanisms i nvolved in tumor progression of this neoplasm. With conventional cytogeneti c techniques (CCT), a complex hyperdiploid karyotype was obtained in stage IV. Using CGH analysis, a normal profile was observed in stage II, whereas gains of 6p11.2, 7q11.2, 7q21-->q32, 7q34, 10p13, Xp11.4, and loss of 4q33- ->qter chromosomal regions were detected in stage IV. (C) Elsevier Science Inc., 2000. All rights reserved.