Systolic and diastolic changes in human coronary blood flow during Valsalva manoeuvre

Valsalva manoeuvre is reported to be sometimes successful for the relief of angina pectoris.;The present study investigated how haemodynamic changes p roduced by Valsalva manoeuvre can interact to improve the relationship betw een cardiac work and coronary blood flow. Ten male subjects aged 53 +/- 12 years (SD) were considered. Blood velocity in the internal mammary artery, previously anastomosed to the left descending coronary artery, was studied with Doppler technique. The subjects performed Valsalva manoeuvres by expir ing into a tube connected to a mercury manometer, to develop a pressure of 40 mmHg. The arterial blood pressure curve was continuously monitored with a Finapres device from a finger of the left hand. During expiratory effort, an increase in heart rate and a decrease in arterial pulse pressure were f ollowed by a more delayed and progressive increase in mean and diastolic pr essures. Systolic blood velocity markedly decreased along with the reductio n in pulse pressure and increase in heart rate. By contrast, diastolic and mean coronary blood velocities did not show any significant change. Since i t is known that the Valsalva manoeuvre strongly reduces stroke volume and c ardiac output, it is likely that a reduction in cardiac work also takes pla ce. Since in diastole, i.e. when the myocardial wall is better perfused, co ronary blood velocity did not show any significant reduction, it is Likely that unchanged perfusion in the presence of reduced cardiac work is respons ible for the relief from angina sometimes observed during Valsalva manoeuvr e. It is also likely that the increase in heart rate prevents the diastolic and mean blood coronary velocity from decreasing during the expiratory str ain, when an increased sympathetic discharge could cause vasoconstriction t hrough the stimulation of the coronary alpha-receptors.