A cellular automaton model of cellular signal transduction

On the basis of cellular automata models, a software specifically tailored to model biochemical reactions involved in cellular signal transduction was implemented on a personal computer. Recent data regarding desensitization processes in mouse Leydig cells are used to simulate the underlying reactio ns of signal transduction. Pretreatment of real Leydig cells with different molecules results in a modification of the signal transduction cascade lea ding to a diminished response of the cells during subsequent stimulations, The model is capable of simulating the complex behavior of this intracellul ar second messenger production in a qualitative and semi-quantitative way. The results indicate that quantitative simulations on a molecular level wil l be possible once appropriate computer hardware is available, The simulati ons and results of the cellular automaton presented are easily described an d comprehended, which make it a useful tool that will facilitate research i n cellular signal transduction and other fields covering complex reaction n etworks, (C) 2000 Elsevier Science Ltd. All rights reserved.