MORPHOLOGICAL AND MOLECULAR CHARACTERISTICS OF LIVING HUMAN FETUSES BETWEEN CARNEGIE STAGE-7 AND STAGE-23 - IMMUNOLOCALIZATION OF INHIBIN-ALPHA AND BETA-A SUBUNITS

Transforming growth factor (TGF) is known to have the ability to modif y mitogenic responses of tissues to other peptide growth factors and t herefore may contribute to the rapid growth rate of an embryo, Through out the TGF superfamily there is a similar fundamental molecular archi tecture, Included in this superfamily are inhibin A, activin A and act ivin B, It has been shown that activin is a powerful mesodermal induci ng factor in the early embryo, The human embryo has shown localization of inhibin in the gonads after 16 weeks gestation but it has not been previously identified in earlier embryos, The inhibin-activin protein was found in a range of tissues including the liver stages 19-21 (alp ha) and stages 19-22 (beta); oesophagus stages 19-22 (alpha and beta); stomach stages 21 and 22 (alpha and beta); gut stages 16-22 (alpha) a nd 21 and 22 (beta); pericardium stages 12-22 (alpha and beta); gonad stages 21 and 22 (beta) stage 22 (alpha); adrenal stages 19-22 (alpha and beta); urogenital system stages 21 and 22 (alpha and beta); yolk s ac stage 12 (alpha and beta); mesenchyme stages 16-22 (alpha); surface ectoderm stages 13-22 (alpha) and stages 16-22 (beta a); notocord sta ges 13-22 (beta) and stages 21 and 22 (alpha); nasal, trachea and bron chi stages 19-22 (alpha and beta) leading to speculation of the role o f both subunits.