Epidemiology of quinolone resistance of Klebsiella pneumoniae and Klebsiella oxytoca in Europe

The epidemiology of quinolone resistance and the concomitant resistance to other antibiotic classes was investigated in 445 Klebsiella pneumoniae and 238 Klebsiella oxytoca isolates. Decreased susceptibility to ciprofloxacin was found in 7.2% and 3.3% of these two species, respectively. Ciprofloxaci n resistance was significantly linked to ceftazidime resistance, the hallma rk of extended-spectrum beta-lactamase production, as well as to resistance to all antibiotic classes tested. Using automated ribotyping, seven intrah ospital- and interhospital-transmitted clones of ciprofloxacin-resistant is olates were found. The newer fluoroquinolones sitafloxacin and clinafloxaci n may become increasingly valuable, since they proved to be active also aga inst ciprofloxacin-resistant isolates.