The human immunoglobulin loci introduced into mice: V (D) and J gene segment usage similar to that of adult humans

Authors
Gallo, ML Ivanov, VE Jakobovits, A Davis, CG
Citation
Ml. Gallo et al., The human immunoglobulin loci introduced into mice: V (D) and J gene segment usage similar to that of adult humans, EUR J IMMUN, 30(2), 2000, pp. 534-540
Citations number
31
Categorie Soggetti
Immunology
Journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN journal
00142980 → ACNP
Volume
30
Issue
2
Year of publication
2000
Pages
534 - 540
Database
ISI
SICI code
0014-2980(200002)30:2<534:THILII>2.0.ZU;2-2
Abstract
Variable gene segments of the human immunoglobulin loci are represented in the human peripheral repertoire at different frequencies. XenoMouse(TM) str ains contain approximately 2 megabases of the human immunoglobulin heavy an d kappa fight chain loci that functionally recapitulate the human humoral i mmune system. Analysis of human antibody transcripts from XenoMouse spleens and lymph nodes revealed that V, D and J gene segment utilization from the se unimmunized animals were nearly identical to the gene segment utilizatio n reported for humans with extensive antigenic histories.