Analysis of association at single nucleotide polymorphisms in the APOE region

The discussion of the prospects of using a dense map of single nucleotide p olymorphisms (SNPs) to identify disease genes with association analysis has been extensive, However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodo logy, we identified 10 SNPs in the region immediately surrounding the apoli poprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin t o investigate the question of whether APOE could have been identified using SNPs, Our strongest evidence of association was at the 2 SNPs immediately flanking APOE. (C) 2000 Academic Press.