VACOP-B, high-dose cyclophosphamide and high-dose therapy with peripheral blood progenitor cell rescue for aggressive non-Hodgkin's lymphoma with bone marrow involvement: a study by the non-Hodgkin's Lymphoma Co-operative Study Group

Background and Objectives. Sequential treatment with the addition of high-d ose therapy (HDT) and peripheral blood progenitor cell (PBPC) rescue has be en reported to be active as front-line therapy in aggressive non-Hodgkin's lymphoma (NHL) with bone marrow (BM) involvement. We designed an intensive sequential therapy as front-line therapy in this subset of patients and con ducted a phase II study. Design and Methods. Patients with aggressive non-Hodgkin's lymphoma and BM involvement at diagnosis received 8 weeks of VACOP-B chemotherapy as Induct ion therapy. The second phase included high-dose cyclophosphamide (HDCY) (7 g/m(2)) with granulocyte colony-stimulating factor (G-CSF) followed by leu kaphereses. The third phase included HDT according to the BEAM protocol or melphalan (140 mg/m(2)) plus total body irradiation (8 Gy in a single dose) . Results. Forty patients were Included in the study. According to the intent ion-to-treat, after VACOP-B, 11 (27.5%) and 22 (55%) patients achieved comp lete remission (CR) and partial remission (PR), respectively. Thirty-four r eceived HDCY. After HDCY, 18 patients (45%) were in CR and 13 (32.5%) in PR . Twenty-nine underwent HDT plus peripheral blood cell rescue (PBPC) rescue . At the completion of treatment 29 patients (72.5%) were in CR, and 3 pati ents (7.5%) in PR. The actuarial 3-year overall survival, disease free surv ival and failure free sur vival are 48%, 55% and 40%, respectively. Overall severe toxicity was 7.5%. Interpretation and Conclusions. This phase tl study suggests that the inten sified treatment described is feasible and active in aggressive NHL with BM involvement. A randomized trial is now underway to test this approach. (C) 2000, Ferrata Storti Foundation.