Fatal bone marrow aplasia during interferon-alpha treatment in chronic myelogenous leukemia

Authors
Chiusolo, P Sica, S Laurenti, L Piccirillo, N Giordano, G Leone, G
Citation
P. Chiusolo et al., Fatal bone marrow aplasia during interferon-alpha treatment in chronic myelogenous leukemia, HAEMATOLOG, 85(2), 2000, pp. 212-212
Citations number
3
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
HAEMATOLOGICA
ISSN journal
03906078 → ACNP
Volume
85
Issue
2
Year of publication
2000
Pages
212 - 212
Database
ISI
SICI code
0390-6078(200002)85:2<212:FBMADI>2.0.ZU;2-9
Abstract
Interferon-alpha (IFN-alpha) has been successfully employed in the treatmen t of several hematologic malignancies. IFN-alpha therapy can cause a variet y of long-term side effects such as thyroid dysfunction, development of oth er autoimmune diseases and the isolated appearance of autoantibodies. In th is paper we describe the occurence of fatal bone marrow aplasia in a patien t with chronic myelogenous leukemia (CML) during IFN-alpha treatment.