Decreased susceptibility to extended-spectrum cephalosporins of a penicillin-susceptible Streptococcus pneumoniae in meningitis

A 69-year-old woman was admitted to the hospital with meningitis due to Str eptococcus pneumoniae, The strain was susceptible to penicillin but interme diate to cefotaxime, In Europe the decrease of susceptibility generally per tains more to penicillin than to cefotaxime, Such a strain is perhaps a for ewarning of the existence of high-level cephalosporin-resistant strains. De spite the possible detection of the resistance by oxacillin disk, it underl ines the need to determine the MICs of different beta-lactams without delay and to choose the most efficient treatment.