Macropinocytosis as a mechanism of entry into primary human urethral epithelial cells by Neisseria gonorrhoeae

Authors
Zenni, MK Giardina, PC Harvey, HA Shao, JQ Ketterer, MR Lubaroff, DM Williams, RD Apicella, MA
Citation
Mk. Zenni et al., Macropinocytosis as a mechanism of entry into primary human urethral epithelial cells by Neisseria gonorrhoeae, INFEC IMMUN, 68(3), 2000, pp. 1696-1699
Citations number
14
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
3
Year of publication
2000
Pages
1696 - 1699
Database
ISI
SICI code
0019-9567(200003)68:3<1696:MAAMOE>2.0.ZU;2-C
Abstract
Gonococcal entry into primary human urethral epithelial cells (HUEC) fan oc cur by macropinocytosis. Scanning and transmission electron microscopy reve aled lamellipodia surrounding gonococci, and confocal laser scanning micros copy analysis showed organisms colocalized with M-r 70,000 fluorescein isot hiocyanate-labeled dextran within the cells. Phosphoinositide 3-kinase inhi bitors and an actin polymerization inhibitor prevented macropinocytic entry of gonococci into HUEC.