Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1 beta levels

Authors
Boelens, JJ Zaat, SAJ Murk, JL Weening, JJ van der Poll, T Dankert, J
Citation
Jj. Boelens et al., Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1 beta levels, INFEC IMMUN, 68(3), 2000, pp. 1692-1695
Citations number
19
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
3
Year of publication
2000
Pages
1692 - 1695
Database
ISI
SICI code
0019-9567(200003)68:3<1692:ESTSAF>2.0.ZU;2-I
Abstract
A persistent Staphylococcus epidermidis infection in mice around a subcutan eous polyvinypyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1 beta (IL-1 be ta) production was found. Apparently, sustained levels of IL-1 beta are ass ociated with enhanced susceptibility to biomaterial-associated S. epidermid is infection.