Effects of iron on extracellular and intracellular growth of Penicillium marneffei

Authors
Taramelli, D Brambilla, S Sala, G Bruccoleri, A Tognazioli, C Riviera-Uzielli, L Boelaert, JR
Citation
D. Taramelli et al., Effects of iron on extracellular and intracellular growth of Penicillium marneffei, INFEC IMMUN, 68(3), 2000, pp. 1724-1726
Citations number
18
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
3
Year of publication
2000
Pages
1724 - 1726
Database
ISI
SICI code
0019-9567(200003)68:3<1724:EOIOEA>2.0.ZU;2-8
Abstract
Killing of intracellular Penicillium marneffei conidia is demonstrated in g amma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cell s. Iron overload significantly reduces the antifungal activity of macrophag es. Likewise, exogenous iron enhances and iron chelators inhibit the extrac ellular growth of P. marneffei. These results suggest that iron availabilit y critically affects immunity to and the pathogenicity of P. marneffei.