A case of T-lineage lymphoblastic lymphoma/leukemia with t(4;11)(q21;p15) that switched to myelomonocytic leukemia at relapse

Authors
Kawakami, K Miyanishi, S Amakawa, R Hayashi, T Kurata, M Nakamura, F Tanaka, Y Ohno, Y Shiku, H
Citation
K. Kawakami et al., A case of T-lineage lymphoblastic lymphoma/leukemia with t(4;11)(q21;p15) that switched to myelomonocytic leukemia at relapse, INT J HEMAT, 69(3), 1999, pp. 196-199
Citations number
13
Categorie Soggetti
Hematology
Journal title
INTERNATIONAL JOURNAL OF HEMATOLOGY
ISSN journal
09255710 → ACNP
Volume
69
Issue
3
Year of publication
1999
Pages
196 - 199
Database
ISI
SICI code
0925-5710(199904)69:3<196:ACOTLL>2.0.ZU;2-M
Abstract
A 51-year-old Japanese woman, initially diagnosed with T-lineage (CD2(+), C D7(+), CD3(-), CD4(-), CD8(-)) lymphoblastic lymphoma with t(4,ll)(q21:p15) , relapsed with acute myelomonocytic leukemia with the identical chromosoma l abnormality. Southern-blot analysis revealed clonal rearrangements of an immunoglobulin heavy chain gene (JH) and T-cell receptor genes (J delta 1, J gamma 1, C beta 1) at fil st presentation, bur germ line configurations o f these genes at relapse, Leukemias with t(4:Il)(q21:p15) may involve a hem atopoietic progenitor capable of multilineage differentiation. (C) 1999 The Japanese Society of Hematology.