EFFECT OF A SINGLE-DOSE OF SOME ANTIANGIN AL DRUGS ON THE STATE OF TACTILE AND PAIN SENSITIVITY OF SKIN IN PATIENTS WITH ANGINA-PECTORIS

In 10 men aged 39-65 years with ischemic heart disease and stable clas s II-III effort angina tactile and pain thresholds were assessed by el ectric skin stimulation (skin electrosensometry). Effects of nifedipin e (20 mg), propranolol (40 mg), verapamil (80 mg), trinitrolong (3 mg) and placebo (2 tests) an these thresholds were evaluated. After nifed ipine increment of tactile threshold (lowering of tactile sensitivity) was substantially greater than after any other drug used in the study or placebo (p=0,0001, Duncan's multiple range test). None of the drug s produced significant elevation of pain threshold. The ability of nif edipine to lower tactile sensitivity might be a factor contributing to development of painless myocardial ischemia.