Simultaneous production of granulocyte colony-stimulating factor and parathyroid hormone-related protein in bladder cancer

A case of bladder cancer with simultaneous production of granulocyte colony -stimulating factor (G-CSF) and parathyroid hormone-related protein (PTHrP) is reported. An 81-year-old male patient was admitted to the Saitama Medic al School for treatment of gross hematuria, leukocytosis and hypercalcemia and diagnosed as having advanced bladder cancer. Immediately after a cystec tomy was carried out, his white cell count and serum calcium levels returne d to normal. However. the tumors recurred locally and the recurrence was ac companied by an increase in the serum G-CSF and PTHrP levels with a recurre nt elevation of white cell count and the serum calcium level. The productio n of G-CSF and PTHrP in the tumor cells was confirmed by immunohistochemist ry.