Use of tissue-type plasminogen activator for acute ischemic stroke - The Cleveland area experience

Context Little is known regarding outcomes after intravenous tissue-type pl asminogen activator (IV tPA) therapy for acute ischemic stroke outside a tr ial setting. Objective To assess the rate of IV tPA use, the incidence of symptomatic in tracerebral hemorrhage (ICH), and in-hospital patient outcomes throughout a large urban community. Design Historical prospective cohort study conducted from July 1997 through June 1998. Setting Twenty-nine hospitals in the Cleveland, Ohio, metropolitan area. Patients A total of 3948 patients admitted to a study hospital with a prima ry diagnosis of ischemic stroke (International Classification of Diseases, Ninth Revision, Clinical Modification code 434 or 436). Main Outcome Measures Rate of IV tPA use and occurrence of symptomatic ICH among patients treated with tPA; proportion of patients receiving tPA whose treatment deviated from national guidelines; in-hospital mortality among p atients receiving tPA compared with that among ischemic stroke patients not receiving tPA and with mortality predicted by a model. Results Seventy patients (1.8%) admitted with ischemic stroke received IV t PA. Of those, 11 patients (15.7%; 95% confidence interval [CI], 8.1%-26.4%) had a symptomatic ICH (of which 6 were fatal) and 50% (95% CI, 37.8%-62.2% ) had deviations from national treatment guidelines. In-hospital mortality was significantly higher among patients treated with tPA (15.7%) compared w ith patients not receiving tPA (5.1%, P<.001) and compared with the model's prediction (7.9%; P<.006). Conclusions A small proportion of patients admitted with acute ischemic str oke in Cleveland received tPA; they experienced a high rate of ICH. Clevela nd community experience with tPA for acute ischemic stroke may differ from that reported in clinical trials.