D. Brasanac et al., HLA class I antigens expression in renal cell carcinoma: Histopathologicaland clinical correlation, J EXP CL C, 18(4), 1999, pp. 505-510
Citations number
26
Categorie Soggetti
Oncology
Journal title
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Immunohistochemical analysis of HLA class I antigens expression in 26 renal
cell carcinomas (RCCs) - 18 clear cell, 6 granular and 2 chromophobe - was
performed with indirect immunoperoxidase method. Results were correlated w
ith extent and immunophenotype of tumor infiltrating mononuclear cells, his
topathological (histology, cytology, grade, presence of necrosis) and clini
cal (tumor diameter, TNM classification) characteristics of RCC. 4 (15%) RC
Cs showed reduced HLA class I presence and this was associated with greater
tumor diameter and more frequent T3,T4 and M1 stage, All tumors with alter
ed HLA class I antigens expression were grade 2 or 3 and strong correlation
with presence of necrosis (p=0,006) was noticed, while mononuclear cell in
filtrates (especially CD8+ T lymphocytes) were less extensive compared to t
umors with normal HLA class I level. Our results suggest more aggressive cl
inical behavior of RCCs with reduced HLA class I antigens expression, proba
bly due to impaired cellular antitumor immune response.