Microvascular endothelium dysfunction during growth of transplanted lymphosarcoma and glioma in rats

The changes of endothelium functional parameters (adhesivity, permeability, thrombogenity and thromboresistance) in mesenteric microvasculature in rat s with two transplanted tumors: fast-growing Pliss' lymphosarcoma (PLS) and slow-growing glioma-35 (G-35) were studied, using a complex method, based upon a computer-assisted microscopic video image processing, The endothelia l dysfunction in mesenteric microvessels is characterized by the increase o f leukocyte adhesion to the endothelial cells, microvessels permeability an d their thromboresistance properties decrease in tumor-bearing rats: The ob served changes are shown to be the nonspecific manifestation of the tumor p rocess development. They are determined by the duration of the process deve lopment and are not dependent on the tumor node size.