Synthesis of two naphthoquinone antibiotics, dehydroherbarin and 6-deoxybostrycoidin

Authors
Kesteleyn, B De Kimpe, N
Citation
B. Kesteleyn et N. De Kimpe, Synthesis of two naphthoquinone antibiotics, dehydroherbarin and 6-deoxybostrycoidin, J ORG CHEM, 65(3), 2000, pp. 640-644
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
65
Issue
3
Year of publication
2000
Pages
640 - 644
Database
ISI
SICI code
0022-3263(20000211)65:3<640:SOTNAD>2.0.ZU;2-I
Abstract
The synthesis of two naphthoquinone antibiotics, dehydroherbarin (7) and 6- deoxybostrycoidin (5), was accomplished by reaction of 3-acetonyl-2-bromome thyl-6,8-dimethoxy-1,4-naphthoquinone (23) with either triethylamine or amm onia, respectively. This is the first report on their synthesis.