Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia
B. Ogretmen et al., Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia, J PED H ONC, 22(1), 2000, pp. 45-49
Immunophenotype might be an important indicator for multidrug resistance (M
DR) profiles in childhood acute lymphoblastic leukemia (ALL). The authors a
nalyzed the messenger RNA (mRNA) levels of MDR1, multidrug resistance-assoc
iated protein (MRP), and lung resistance-related protein (LRP) by reverse t
ranscriptase-polymerase chain reaction (RT-PCR) in childhood pre-B ALL, T-c
ell ALL, and acute nonlymphoblastic leukemia (ANLL). Results showed that MR
P and LRP, but not MDR1, mRNAs are overexpressed, particularly in children
with pre-B ALL compared with T-cell ALL and ANLL tested. In addition, the M
RP and LRP mRNA expression levels in initial diagnosis and first relapse sa
mples of one patient with pre-B ALL were similar. Consequently, these preli
minary results suggest that the expression of these MDR-related genes in ch
ildhood ALL might be regulated differently in a lineage dependent manner.