Osteosarcoma associated with absent thumbs: A report of two cases

Citation
L. Orme et al., Osteosarcoma associated with absent thumbs: A report of two cases, J PED H ONC, 22(1), 2000, pp. 73-77
Citations number
34
Categorie Soggetti
Pediatrics
Journal title
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
ISSN journal
10774114 → ACNP
Volume
22
Issue
1
Year of publication
2000
Pages
73 - 77
Database
ISI
SICI code
1077-4114(200001/02)22:1<73:OAWATA>2.0.ZU;2-K
Abstract
An 8-year-old Hispanic boy with a hypoplastic left thumb, absent right thum b, and short stature experienced right leg pain and limp. A right tibial le sion was imaged and found to be osteosarcoma on biopsy. A 6-year-old Hispan ic girl with congenitally absent thumbs experienced a pathologic fracture o f her left femur after a minor sports injury. The radiologic abnormality se en was diagnosed as osteosarcoma on biopsy. Both patients continue to do we ll after intensive preoperative and postoperative high-dose chemotherapy an d definitive reconstructive limb surgery. Osteosarcoma has been linked to s everal congenital syndromes in which absent thumbs are a feature. These two patients with absent thumbs and no definable syndrome experiencing osteosa rcoma suggest that congenitally absent thumbs might be a risk factor for os teosarcoma in the absence of a syndrome.