Spectrophotometry assay of imipramine and desipramine using ammonium metavanadate and its application to pharmaceutical preparations

Simple and sensitive method for determination of imipramine: and desipramin e is reported. The procedure is based on the oxidation of the drugs by ammo nium metavanadate. Linear calibration graphs were obtained in the concentra tion range 0.6-40 mu g ml(-1) of imipramine and 0.7-35 mu g ml(-1) of desip ramine with a relative standard deviation (RSD) less than 0.5%. The method was applied to the determination of the drugs in pharmaceutical preparation s and compared favourably with independent official methods. (C) 2000 Elsev ier Science B.V. All rights reserved.