The manufacture of pharmaceuticals requires clean processing. Wipers are us
ed to remove contaminants, such as chemical films, microbiological entities
, and nonbiological particles, by wiping the walls, tables, and equipment a
nd to inhibit biological activity by applying disinfectants. Cleaning proto
cols can be validated using clean swabs for sampling and sensitive instrume
ntation for quantification. The characteristics of wipers and swabs suitabl
e for these purposes are explored.