The treatment of substituted ethyl 1-(3',4'-dihydro-3',3'-dimethylisoquinol
yl)-1-oximinoacetates with hydrazine hydrate leads to a 3,4-dihydroisoquino
line ring enlargement with the annulation of a pyrazole ring to form substi
tuted 5,5-dimethyl-2,3,5,6-tetra-hydro-3-oxopyrazolo[3,4-b]benzo-3-azepines
.