Citation
Rvs. Raju et al., N-myristoyltransferase, MOL C BIOCH, 204(1-2), 2000, pp. 135-155
Citations number
165
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR AND CELLULAR BIOCHEMISTRY
ISSN journal
03008177
→ ACNP
Volume
204
Issue
1-2
Year of publication
2000
Pages
135 - 155
Database
ISI
SICI code
0300-8177(200001)204:1-2<135:N>2.0.ZU;2-O
Abstract
Myristoylation refers to the co-translational addition of a myristoyl group
to an amino-terminal glycine residue of a protein by an ubiquitously distr
ibuted enzyme myristoyl-CoA:protein N-myristoyltransferase (NMT, EC 2.3.1.9
7). This review describes the basic enzymology, molecular cloning and regul
ation of NMT activity in various pathophysiological processes such as colon
cancer and diabetes.