We carry out N-body simulations of several non-Gaussian structure formation
models, including Peebles' isocurvature cold dark matter model, cosmic str
ing models, and a model with primordial voids. We compare the evolution of
the cluster mass function in these simulations with that predicted by a mod
ified version of the Press-Schechter formalism. We find that the Press-Sche
chter formula can accurately fit the cluster evolution over a wide range of
redshifts for all of the models considered, with typical errors in the mas
s function of less than 25 per cent, considerably smaller than the amount b
y which predictions for different models may differ. This work demonstrates
that the Press-Schechter formalism can be used to place strong model-indep
endent constraints on non-Gaussianity in the Universe.