Stable weight during lamotrigine therapy: A review of 32 studies

Authors
Devinsky, O Vuong, A Hammer, A Barrett, PS
Citation
O. Devinsky et al., Stable weight during lamotrigine therapy: A review of 32 studies, NEUROLOGY, 54(4), 2000, pp. 973-975
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
54
Issue
4
Year of publication
2000
Pages
973 - 975
Database
ISI
SICI code
0028-3878(20000222)54:4<973:SWDLTA>2.0.ZU;2-W
Abstract
A side effect associated with the use of some antiepileptic drugs (AEDs) is change in body weight. To evaluate the effect of lamotrigine on body weigh t in adult patients with epilepsy, we conducted a retrospective review of d ata from 463 patients treated with lamotrigine in 32 clinical trials. Mean daily dose was 259 (+/-155) mg and duration of therapy was 318 (+/-87) days . The mean change in body weight was 0.5 (+/-5) kg. Lamotrigine was associa ted with stable body weight in patients with epilepsy.