mtDNA A3243G: MELAS mutation is not associated with multigenerational female migraine

Authors
Buzzi, MG Di Gennaro, G D'Onofrio, M Ciccarelli, O Santorelli, FM Fortini, D Nappi, G Nicoletti, F Casali, C
Citation
Mg. Buzzi et al., mtDNA A3243G: MELAS mutation is not associated with multigenerational female migraine, NEUROLOGY, 54(4), 2000, pp. 1005-1007
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
54
Issue
4
Year of publication
2000
Pages
1005 - 1007
Database
ISI
SICI code
0028-3878(20000222)54:4<1005:MAMMIN>2.0.ZU;2-7
Abstract
The authors searched for mitochondrial DNA (mtDNA) A3243G mutation in perip heral blood leukocytes from female migraine patients with pure matrilinear history of migraine along two or three generations. The current study was d esigned to exclude any male transmission of the disease. The mutation was a bsent in all patients. We conclude that mtDNA A3243G mutation does not cont ribute to the pathogenesis of pure matrilinear multigenerational migraine w ith or without aura.