The authors searched for mitochondrial DNA (mtDNA) A3243G mutation in perip
heral blood leukocytes from female migraine patients with pure matrilinear
history of migraine along two or three generations. The current study was d
esigned to exclude any male transmission of the disease. The mutation was a
bsent in all patients. We conclude that mtDNA A3243G mutation does not cont
ribute to the pathogenesis of pure matrilinear multigenerational migraine w
ith or without aura.