Absolute configuration of scyphostatin

Authors
Saito, S Tanaka, N Fujimoto, K Kogen, H
Citation
S. Saito et al., Absolute configuration of scyphostatin, ORG LETT, 2(4), 2000, pp. 505-506
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
4
Year of publication
2000
Pages
505 - 506
Database
ISI
SICI code
1523-7060(20000224)2:4<505:ACOS>2.0.ZU;2-Y
Abstract
[GRAPHICS] The absolute configuration of the side chain of scyphostatin (1) has been e stablished. The chemical degradation of 1 gave 4 and 9, which correspond to the C7'-C12' and C13'-C16' fragments of the natural products, respectively . The spectroscopic data and [alpha](D) values of both compounds were compa red to those of authentic samples. The results show that the absolute confi guration of 1 is 8'R,10'S,14'R.