Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea

Authors
Chang, LC Chavez, D Song, LL Farnsworth, NR Pezzuto, JM Kinghorn, AD
Citation
Lc. Chang et al., Absolute configuration of novel bioactive flavonoids from Tephrosia purpurea, ORG LETT, 2(4), 2000, pp. 515-518
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
4
Year of publication
2000
Pages
515 - 518
Database
ISI
SICI code
1523-7060(20000224)2:4<515:ACONBF>2.0.ZU;2-R
Abstract
[GRAPHICS] Three novel flavonoids, (+) tephrorins A (1) and B (2) and (+)-tephrosone ( 3), were isolated from Tephrosia purpurea, Their structures were elucidated by NMR spectral analysis, and their absolute configurations were determine d by Mosher ester methodology. Compounds 1 and 2 are flavanones containing an unusual tetrahydrofuran moiety, Compounds 1-3 were evaluated for their p otential cancer chemopreventive properties using a cell based quinone reduc tase induction assay.