A novel synthesis of 2-aryl-2H-indazoles via a palladium-catalyzed intramolecular amination reaction

Authors
Song, JJ Yee, NK
Citation
Jj. Song et Nk. Yee, A novel synthesis of 2-aryl-2H-indazoles via a palladium-catalyzed intramolecular amination reaction, ORG LETT, 2(4), 2000, pp. 519-521
Citations number
34
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
4
Year of publication
2000
Pages
519 - 521
Database
ISI
SICI code
1523-7060(20000224)2:4<519:ANSO2V>2.0.ZU;2-I
Abstract
[GRAPHICS] A variety of 2-aryl-2H-indazoles were synthesized by the palladium-catalyze d intramolecular amination of the corresponding N-aryl-N-(o- bromobenzyl)hy drazines. Of several sets of reaction conditions surveyed, the combination of Pd(OAc)(2)/dppf/tBuONa gave the best results. This method applies to a w ide scope of substrates containing electron donating and electron-withdrawi ng substituents.