We present a consistent framework of coupled classical and quantum dynamics
. Our result allows us to overcome severe limitations of previous phenomeno
logical approaches, such as evolutions that do not preserve the positivity
of quantum states or that allow one to activate quantum nonlocality for sup
erluminal signaling. A "hybrid" quantum-classical density is introduced, an
d its evolution equation derived. The implications and applications of our
result are numerous: it incorporates the back-reaction of quantum on classi
cal variables, and it resolves fundamental problems encountered in standard
mean-field theories, and remarkably, also in the quantum measurement proce
ss; i.e., the most controversial example of quantum-classical interaction i
s consistently described within our approach, leading to a theory of dynami
cal collapse.