The multidimensional N=4 supersymmetric (SUSY) quantum mechanics (QM) is co
nstructed using the superfield approach. As a result, the component form of
the classical and quantum Lagrangian and Hamiltonian is obtained. In the S
USY QM considered, both classical and quantum N=4 algebras include central
charges, and this opens various possibilities for partial supersymmetry bre
aking. It is shown that quantum-mechanical models with one-quarter, one-hal
f, and three-quarters of unbroken (broken) supersymmetries can exist in the
framework of the multidimensional N=4 SUSY QM, while the one-dimensional N
=4 SUSY QM, constructed earlier, admits only one half or total supersymmetr
y breakdown. We illustrate the constructed general formalism, as well as al
l possible cases of partial SUSY breaking taking as an example a direct mul
tidimensional generalization of the one-dimensional N=4 superconformal quan
tum-mechanical model. Some open questions and possible applications of the
constructed multidimensional N=4 SUSY QM to the known exactly integrable sy
stems and problems of quantum cosmology are briefly discussed.