Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae)

Authors
Asano, N Nishida, M Miyauchi, M Ikeda, K Yamamoto, M Kizu, H Kameda, Y Watson, AA Nash, RJ Fleet, GWJ
Citation
N. Asano et al., Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae), PHYTOCHEM, 53(3), 2000, pp. 379-382
Citations number
9
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
53
Issue
3
Year of publication
2000
Pages
379 - 382
Database
ISI
SICI code
0031-9422(200002)53:3<379:PPAPAF>2.0.ZU;2-E
Abstract
Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloid s, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrr olidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkalo ids 1,4dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymanno jirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glu cosidase (IC50 = 68 mu M), whereas alpha-1-C-ethyl-fagomine inhibited bovin e liver beta-galactosidase (IC50 = 29 mu M) (C) 2000 Elsevier Science Ltd. All rights reserved.