Screening of the needles of different yew species and cultivars for paclitaxel and related taxoids

Authors
van Rozendaal, ELM Lelyveld, GP van Beek, TA
Citation
Elm. Van Rozendaal et al., Screening of the needles of different yew species and cultivars for paclitaxel and related taxoids, PHYTOCHEM, 53(3), 2000, pp. 383-389
Citations number
14
Categorie Soggetti
Agricultural Chemistry","Animal & Plant Sciences
Journal title
PHYTOCHEMISTRY
ISSN journal
00319422 → ACNP
Volume
53
Issue
3
Year of publication
2000
Pages
383 - 389
Database
ISI
SICI code
0031-9422(200002)53:3<383:SOTNOD>2.0.ZU;2-X
Abstract
The needles of several yew species and cultivars were analysed by high-pres sure liquid chromatography for paclitaxel, 10-deacetylpaclitaxel, cephaloma nnine, baccatin III, 10-deacetylbaccatin III and brevifoliol. About 750 sam ples were collected from five different locations in the Netherlands and th e UK. The results of this screening show a large variation in taxane conten t between the different species and cultivars. The content of paclitaxel an d 10-deacetylbaccatin III varied from 0 to 500 mu g/g and 0 to 4800 mu g/g dried needles. respectively. Brevifoliol was found Deacetylpaclitaxel, ceph alomannine and baccatin III were found needles. (C) 2000 Elsevier Science L td. All rights reserved.