A convenient synthesis of novel hydrazones and osazones of 2-hydrazino-3-phenyl-4(3H)-quinazolinone

A series of the hydrazones 3 was prepared in very good yields by the reacti on of 2-hydrazino-3-phenyl-4(3H)-quinazolinone (1) with monosaccharides 2. Acetylation of the hydrazones using acetic anhydride in the presence of pyr idine at room temperature gave the coresponding acetyl derivatives 4 in exc ellent yields. The reaction of three equivalents of 1 with one equivalent o f monosaccharides 2 in acetic acid afforded the corresponding osazones 5 in poor yields. Acetylation of the osazones using acetic anhydride in the pre sence of pyridine at room temperature afforded the corresponding acetyl der ivatives 6 in good yields.