Eosinophilic fasciitis (Shulman's syndrome)

We report on a 35-year-old female with eosinophilic fasciitis (Shulman's sy ndrome). The characteristic features of this disease are scleroderma-like s kin indurations, predominantly on the extremities, with joint contractures and intermittent blood eosinophilia. Histologic findings include fibrosis o f muscle fascia and eosinophilic infiltration. Systemic corticosteroid ther apy usually results in remission of symptoms. In this case refractory to sy stemic corticosteroids, we report for the fist time a successful therapy us ing cyclophosphamide.