The impact on patient care of interventions made by a liaison clinical
pharmacist visiting a busy inpatient palliative care unit were evalua
ted using a validated six-point scoring system. Interventions made in
13% of patients could improve patient care, save money or both, but ra
rely involved the drugs that are commonly used for symptom control in
patients with terminal cancer. Advice to rationalize inappropriate dru
g regimens (53%) was the commonest intervention, followed by warnings
about drug interactions (24%) and advice about therapeutic drug monito
ring (8%). The interventions were evaluated by the pharmacist, a palli
ative medicine registrar and two independent doctors, confirming that
the pharmacist was valid and accurate in assessing her own work. Altho
ugh more than 60% of interventions could significantly improve patient
care, compliance by medical and nursing staff with advice was only 55
%, reflecting possible tensions between palliative and general hospita
l medicine. This survey emphasizes the role of liaison clinical pharma
cists in palliative care, the need for much more critical appraisal of
prescribing practices and the utility of ranking pharmacist intervent
ions as a quality assurance and educational tool. In particular, provi
ding palliative care for patients with advanced acquired immunodeficie
ncy syndrome (AIDS) is enhanced when a pharmacist with a specialist kn
owledge of AIDS therapeutics is available.