Surgical treatment of primary midbrain gliomas

BACKGROUND The treatment of brainstem gliomas remains controversial. This article focu ses on surgical results. METHODS The authors retrospectively analyzed 35 patients with primary midbrain glio mas who were treated at Beijing Neurosurgical Institute from 1986 to 1997. The diagnosis was verified by histological examination. RESULT The incidence of midbrain glioma was 10.3% (35/340) in our patients with br ain stem tumors. The 35 gliomas were classified into three therapeutic grou ps by their locations: 7 were located in the tectal region, 8 in the aquedu ctal region, and 20 in the tegmental region. All of the patients underwent microsurgical treatment based on a minimally invasive approach. The operati on took the form of total resection in 19 cases, subtotal resection in 12, and partial resection in 4. The operative mortality was 0, With a mean foll ow-up of 28 months (range, 6-48 months), 65.7% (23/35) of patients could li ve independently. CONCLUSION The volume and location of midbrain tumors were highly correlated with outc ome. The resection of as much tumor as possible was optimal for the treatme nt of midbrain gliomas and radiotherapy after operation was beneficial to p atients. (C) 2000 by Elsevier Science Inc.