Initial formation of deoxybenzoin 3 from phenyl acetic acid 1 and phenol 2
in the presence of BF3.Et2O followed by its treatment at room temperature w
ith N, N'-dimethyl (chloromethylene) ammonium chloride, generated by reacti
ng PCI, with DMF provides a mild and efficient route for a "one pot" synthe
sis of Isoflavones in high yields.