Enantioselective addition of diethylzinc to aldehydes with novel chiral C-2-symmetric dimeric ligands

Authors
Okaniwa, M Yanada, R Ibuka, T
Citation
M. Okaniwa et al., Enantioselective addition of diethylzinc to aldehydes with novel chiral C-2-symmetric dimeric ligands, TETRAHEDR L, 41(7), 2000, pp. 1047-1050
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
7
Year of publication
2000
Pages
1047 - 1050
Database
ISI
SICI code
0040-4039(20000212)41:7<1047:EAODTA>2.0.ZU;2-A
Abstract
Novel (S)-valinol-based chiral C-2-2,2'-ethylenediiminodiethanol derivative s 4a and 4b have been synthesized and used as chiral catalysts in the enant ioselective addition of diethylzinc to aldehydes. (R)-1-Phenylpropanol has been obtained in up to 91% enantiomeric excess. (C) 2000 Elsevier Science L td. All rights reserved.