E. Kolb et al., The importance of the adipozyte hormone for the regulation of food intake,metabolism and reproduction, TIER UMSCH, 55(2), 2000, pp. 79-84
Leptin, a hormone of adipocytes, is a low molecular protein comprising 146
amino acids. After binding to receptors is elicits an activation of protein
kinases and of transcription. Receptors exist in most tissues. An increase
in the proportion of adipose tissue in the body and in the content of Lept
in in the plasma inhibit food intake by influencing the synthesis of neurop
eptides in the hypothalamus and therefore of neuropeptide Y. Leptin increas
es the secretion of various hormones and the oxidation of glucose and fatty
acids and results in reducing the secretion and lipogenetic activity of in
sulin. It stimulates the secretion of LH releasing hormone, FSH and LH, and
the maturation and function of the reproductive organs.