Integrin signalling: a new Cas(t) of characters enters the stage

Citation
Cm. O'Neill et al., Integrin signalling: a new Cas(t) of characters enters the stage, TR CELL BIO, 10(3), 2000, pp. 111-119
Citations number
83
Categorie Soggetti
Cell & Developmental Biology
Journal title
TRENDS IN CELL BIOLOGY
ISSN journal
09628924 → ACNP
Volume
10
Issue
3
Year of publication
2000
Pages
111 - 119
Database
ISI
SICI code
0962-8924(200003)10:3<111:ISANCO>2.0.ZU;2-T
Abstract
Cellular morphology is determined by the organization of the intracellular actin cytoskeleton, which is influenced by external and internal cues. Foca l adhesions are sites at which the actin cytoskeleton is linked to the extr acellular matrix by integrin receptor complexes. In addition to providing s tructural tethering points for cells, integrin receptor complexes transduce signals that influence a broad range of cellular processes, including migr ation, proliferation, transformation and apoptosis. The Cas proteins (p130C as, HEF1/Cas-L and Efs/Sin), a family of docking proteins containing multip le interaction domains, are important components of integrin receptor signa lling and have been implicated in all of these processes.