New 1,4-dihydropyridine derivatives with C4 heterocyclic substituents

4-(2-Pyrrolyl)-2,6-dimethyl-1, 4-dihydropyridine-3,5-bis(methoxycarbonyl), 4-(3-furyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxycarbonyl) and 4 -(3-bromo-2-furyl)-2,6-dimethyl-1,4-dihydropyridine-3.5-bis(methoxycarbonyl ) are potential antiarrhythmic pharmaceuticals with Ca2+ antagonistic activ ity in L type voltage gated channels. Conformation of the 3 and 5 substitut ed carbonyl groups appears influenced by hydrogen bonding with ap orientati on observed for carbonyl groups serving as H-bonding acceptor groups in the solid. This behavior appears to mimic in vivo conformational preferences.